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Biology and mathematics are perhaps the closest disciplines in science -

Biology and mathematics are perhaps the closest disciplines in science


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Any layer of biological system is a complex computing machinery that is under mathematical rules. Biological objects are the products of the most advanced computational machines in the universe. 
Living organisms are the realization of mathematic principles. 
In life, there is no fate, but there are rules that calculate/form fates. Those fates(or fate generating components and rules) are best encoded in biological storage such as genome (genotype) and operated and realized(as appear in phenotypes) by proteins and their complex interaction networks.

The ultimate mathematical machine we know is life that evolves by exploring the information space under mathematical principles.

Life is the logicist's machine of mathematics. In other words, life is the actual calculator, operating system, and realization of mathematics. 

Atomic and subatomic interactions are low level information processing units, bioswitches, that are the components of mathematical circuits.

The Centriole

The Mother Centriole Plays an Instructive Role in Defining Cell Geometry 

"The centriole is unique among cellular structures in its complexity, chirality, stability, and templated replication, and these features make it an ideal hub around which to organize and propagate particular aspects of cellular geometry."

The Telomere Counting Mechanism

The search for the molecular counting mechanism ended when Calvin Harley and Carol Greider discovered that the telomeres of cultured normal human fibroblasts become shorter each time the cells divide. When telomeres reach a specific short length, they signal the cell to stop dividing. Therefore, cellular aging, as marked by telomere shortening, is not based on the passage of time. Instead, telomere loss measures rounds of DNA replication. For this reason, Hayflick has coined the term "replicometer" for this mechanism.

  1. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC...

  2. Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, ...

  3. Previous Article | Table of Contents | Next Article . Progressive Telomere Shortening in Aplastic Anemia Sarah E. Ball, Frances M. Gibson, Siân Rizzo, Jennifer A.

  4. Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 Published online before print January 15, 2004, doi: 10.1161/01.ATV.0000117200.46938.e7

  5. Telomere shortening & metabolic/vascular diseases M. Balasubramanyam, A. Adaikalakoteswari, S. Finny Monickaraj & V. Mohan Madras Diabetes Research Foundation & Dr Mohan's Diabetes ...

  6. One Response to “Telomere shortening and cardiovascular disease”. * Oki. Says: December 15, 2006 at 1:52 am somone in the schneider lab told me that they ...

Lesson from Insect Eye for Computer Vision

Studying neurobiological mechanisms in insect eyes (left) reveals fundamental features of how they detect visual features such as motion (centre). This conceptual understanding (centre) can then help develop artificial, electronic circuits (“microchips”) to achieve the same result (right).
Source: David O’Carroll and colleagues, University of Adelaide, member of SANI


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