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Autism: A Case Study - Biomatics.org

Autism: A Case Study

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Key protein involved in the development of autism discovered

Researchers have been able to find correlations between defects in the expression and/or function of about 200 genes and susceptibility to autism.

 

Date:

August 16, 2018

Source:

Institute for Research in Biomedicine (IRB Barcelona)

Summary:

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism, according to new research.

An international team headed by José Lucas, researcher at the Spanish National Research Council (CSIC) and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), and by Raúl Méndez, researcher at the Institute for Research in Biomedicine (IRB Barcelona), has discovered that CPEB4, a molecule that regulates protein synthesis, is impaired in most cases of autism. The scientists observed that the defects in CPEB4 lead to the dysregulation in the expression of most of these 200 genes. The study has been published in the journal Nature.

 

"this study is an example of how the expression of hundreds of genes must be perfectly coordinated to ensure the correct function of organs and the cells that make up these organs.

 

"Since CPEB4 is known to regulate numerous genes during embryonic development, this protein emerges as a possible link between environmental factors that alter brain development and the genes that predispose to autism,"

 

"Since CPEB4 is known to regulate numerous genes during embryonic development, this protein emerges as a possible link between environmental factors that alter brain development and the genes that predispose to autism,"

 

https://www.sciencedaily.com/releases/2018/08/180816101955.htm

https://www.nature.com/articles/s41398-018-0098-6


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